What's in ALTISNOOZE & why?

In this blog post we'll address the question: What ingredients are in ALTISNOOZE & what function does each perform?

First, a word about how ALTISNOOZE was developed. 

Our team of formulators brings over three decades of experience, with a strong emphasis on the use of botanicals (medicinal plants). We sought to combine the best of traditional medicine with modern, fact-based research. Hundreds of ingredients were explored, many with use dating back thousands of years. In tandem, we scoured the scientific literature for strong clinical evidence pointing to an ingredient's potential. 

The resulting formula features clinically validated doses of key ingredients to support both altitude acclimatization and sleep. Below, we explain what each ingredient is, why it’s beneficial, and provide citations to related research. 

ACCLIMATIZATION & OXYGENATION SUPPORT

Cordyceps Mushroom Extract (RealCordyceps™):

• What It Is: RealCordyceps™ is a premium mushroom extract sourced from the Cordyceps mushroom, traditionally used in Chinese medicine.
• Why It's Beneficial: This potent adaptogen improves oxygen utilization and stamina, making it ideal for those dealing with high-altitude environments. By boosting oxygen efficiency and cell’s tolerance to hypoxic (low-oxygen) conditions, Cordyceps can help reduce fatigue and support the body’s adaptation to altitude, leading to better performance and recovery. Related research: (1), (2)

Humate Mineral Powder (MLG-50™)

• What It Is: Humate Mineral Powder, sourced from ancient plant matter, contains trace minerals, electrolytes, and fulvic acid. It is similar to Shalajit, traditionally used in Ayurvedic medicine to support optimal athletic function at high altitude. 
• Why It's Beneficial: Fulvic acid is a natural chelator that helps the body absorb and utilize nutrients more effectively, promoting cellular energy and recovery. Its role in supporting oxygenation and detoxification is valuable at high altitudes, where the body experiences greater oxidative stress. Related research (1) (2)

N,N-Dimethylglycine HCl (DMG):

• What It Is: DMG is an amino acid derivative found in small amounts in foods like beans and liver.
• Why It's Beneficial: DMG enhances the body’s oxygen utilization and helps improve endurance and recovery, making it valuable in high-altitude environments. Its ability to improve oxygen flow supports better recovery and more restful sleep. Related research: (1)

Vitamin C (Ascorbic Acid):

• What It Is: Vitamin C is a water-soluble essential vitamin and one of the body's most important antioxidants.
• Why It's Beneficial: At high altitude, the body generates significantly more reactive oxygen species due to hypoxic stress and increased respiratory rate. Vitamin C neutralizes these free radicals, supports immune function (relevant for travel and exposure to new environments), and helps regenerate other antioxidants like vitamin E after they've done their work. Research has demonstrated that antioxidant vitamin supplementation can reduce symptoms of acute mountain sickness and protect against altitude-related oxidative damage. Related research: (1), (2)

Vitamin E (alpha-Tocopherol):

• What It Is: Vitamin E is a fat-soluble antioxidant that protects cell membranes from oxidative damage. ALTISNOOZE uses the alpha-tocopherol form, the most biologically active and well-studied version.
• Why It's Beneficial: While Vitamin C works in the water-based parts of your cells, Vitamin E works in the fatty membranes — together they provide complete antioxidant coverage. At altitude, where oxidative stress is elevated and lipid peroxidation (damage to fatty membranes) increases, this dual coverage is especially valuable. Studies have shown Vitamin E supplementation reduces markers of lipid peroxidation under high-altitude and hypoxic conditions. Related research: (1), (2)

Calcium (as Calcium Citrate):

• What It Is: Calcium is an essential mineral and electrolyte involved in nerve transmission, muscle function, and neurotransmitter signaling. ALTISNOOZE uses calcium citrate for its superior absorption — unlike calcium carbonate, it doesn't require stomach acid to be absorbed, making it gentler and more reliably bioavailable.
• Why It's Beneficial: Calcium is the ingredient most electrolyte and hydration products skip entirely. We deliberately include it in ALTISNOOZE for two reasons that matter especially in a sleep formula. First, calcium and magnesium work as natural counterparts in muscle and nerve function — calcium signals muscles to contract, magnesium signals them to relax. Getting both, in balance, is what supports the kind of deep physical relaxation that lets you fall and stay asleep. Second, calcium is required by the pineal gland to convert tryptophan into serotonin, and then serotonin into melatonin — meaning your body literally needs calcium to manufacture the hormones that initiate sleep. Related research: (1), (2)

Sodium (as Pink Himalayan Salt):

• What It Is: Sodium is an essential electrolyte critical for fluid balance, nerve transmission, and blood pressure regulation. ALTISNOOZE sources its sodium from pink Himalayan salt, which contains trace amounts of additional minerals beyond standard sodium chloride.
• Why It's Beneficial: At altitude, you lose more fluid than you realize. Faster respiration, lower humidity, and altitude-driven diuresis all conspire to drain your body of water and electrolytes. Adequate sodium intake helps you retain the fluid you drink, maintains plasma volume, and prevents the dehydration that compounds altitude symptoms and disrupts sleep quality. Pink Himalayan salt provides sodium in its naturally-occurring mineral-complex form, with trace amounts of magnesium, potassium, and other minerals from its ancient sea-salt origin. Related research: (1), (2)

Potassium (as Potassium Citrate):

• What It Is: Potassium is an essential electrolyte and the counterpart to sodium in maintaining cellular fluid balance, nerve transmission, and muscle function. ALTISNOOZE uses potassium citrate, a well-absorbed form that also provides a gentle alkalinizing effect on the body.
• Why It's Beneficial: Altitude exposure increases aldosterone activity, which causes your body to excrete more potassium than it would at sea level. Combined with sweat losses from daytime exertion, your potassium stores can be meaningfully depleted by bedtime. Replenishing potassium supports muscle relaxation (helping prevent the nighttime leg cramps that can wake you up at altitude), maintains steady heart rhythm, and balances sodium for proper hydration. The citrate form provides additional mild alkalinizing benefit, which may help counter altitude-related acid-base shifts. Related research: (1), (2)

SLEEP SUPPORT

Magnesium Bisglycinate:

• What It Is: Magnesium bisglycinate is a highly bioavailable form of magnesium bound to glycine, an amino acid. It absorbs well without the laxative effect common to cheaper forms of
• Why It's Beneficial: Magnesium pulls double duty in ALTISNOOZE. As an electrolyte, it's lost through perspiration and increased respiration at altitude — and most hydration products either skip it or use poorly absorbed forms. As a sleep aid, magnesium relaxes muscles and potentiates GABA, the body's primary calming neurotransmitter. The bisglycinate form delivers an added bonus: glycine itself supports relaxation and helps lower core body temperature ahead of sleep. Related research: (1), (2)

GABA (Gamma-Aminobutyric Acid) (PharmaGABA™):

• What It Is: GABA is the body's primary calming neurotransmitter. PharmaGABA™ is a more bioavailable, fermented form of otherwise synthetically produced GABA.
• Why It's Beneficial: GABA helps reduce anxiety and promotes a calming effect on the brain. Research conducted specifically on PharmaGABA found that subjects fell asleep in less time, moved more rapidly into deep sleep, and experienced more deep, non-REM sleep. Related research: (1), (2)

Apigenin

• What It Is: Apigenin is a natural flavonoid found in chamomile, parsley, and other plants, long associated with calming herbal teas.
• Why It's Beneficial: Apigenin promotes relaxation by binding to benzodiazepine receptors on GABA-A receptors in the brain, helping calm the nervous system and promote sleep onset. Clinical studies of chamomile extracts (a natural source of apigenin) have shown improvements in sleep quality and insomnia symptoms. Related research: (1), (2)

Valerian Root Extract (Sleeproot®)

• What It Is: Valerian (Valeriana officinalis) is a medicinal plant whose root has been used for centuries in European and Asian herbal traditions to promote relaxation and sleep. ALTISNOOZE uses Sleeproot®, a clinically studied, standardized valerian extract from OmniActive that ensures consistent levels of key active compounds for reliable potency and quality.
• Why It's Beneficial: Valerian supports relaxation by influencing GABA activity in the brain, helping calm the nervous system and reduce the time it takes to fall asleep. (1), (2). In addition to its sleep-supporting properties, valerian has demonstrated mild adaptogenic activity in stress models involving cold and low-oxygen conditions. These properties have contributed to its traditional use in Himalayan herbal medicine to support resilience in high-altitude environments. Related Research: (1)

L-Theanine

• What It Is: L-Theanine is an amino acid found in green tea leaves.  
• Why It's Beneficial: Sourced from tea, L-Theanine promotes relaxation by encouraging alpha brain waves, which are associated with calm, focused mental states. This provides for non-sedative sleep support. Related research: (1), (2)

Vitamin B6 (Pyridoxal-5-Phosphate)

• What it is: B6 is a water-soluble essential vitamin.
  
• Why It's Beneficial: B6 aids in the production of serotonin, a key neurotransmitters that helps regulate mood and sleep. Related research: (1), (2)

Lastly, it's worth noting what's NOT in ALTISNOOZE: melatonin. We wrote an extensive blog here explaining this choice. If you want the TLDR:

• Melatonin does nothing to address the core issue of low oxygen availability at elevation. This limits its efficacy to address sleep disruption that's due to altitude.
• The evolving science behind melatonin raises safety concerns, shared among others by Dr. Matthew Walker, renowned neuroscientist and author of Why We Sleep. 

The ingredients in ALTISNOOZE work together to safely promote sleep by addressing the underlying oxygenation and stress issues that often prevent getting quality rest at high altitudes. The formula simultaneously provides gentle sleep support.

In addition, by fostering oxygenation, ALTISNOOZE also helps prevent other common symptoms of elevation like headache, fatigue, and nausea, which can complicate sleep and otherwise spoil a trip to altitude.

Hopefully this has been helpful and informative. Please reach out to us with any questions.

Will & Team